Kary Mullis
American biochemist
Kary Mullis
Kary Banks Mullis is a Nobel Prize winning American biochemist, author, and lecturer. In recognition of his improvement of the polymerase chain reaction (PCR) technique, he shared the 1993 Nobel Prize in Chemistry with Michael Smith and earned the Japan Prize in the same year. The process was first described by Kjell Kleppe and 1968 Nobel laureate H. Gobind Khorana, and allows the amplification of specific DNA sequences.
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Kary Mullis's personal information overview.
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One Advisor’s Soothing Investment Strategy for Retirees
Wall Street Journal - about 2 months
Merrill Lynch’s Mary Mullin likes high-quality munis for those who have lost a regular paycheck.
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Wall Street Journal article
Book Review: Mindful Molecules
Huffington Post - about 3 years
In contrast to the war on drugs, MAPS wants psychedelics and substances such as marijuana and MDMA adopted as prescription medicines. The acronym stands for Multidisciplinary Association for Psychedelic Studies. This non-profit group has just made available Manifesting Mind, a book that describes some of the positive uses of what a friend of mine calls "mindful molecules." A physician would prescribe them and you could then buy them at a pharmacy. This would be one middle way between free-for-all legalization and the prohibition that started under Nixon and has led, MAPS argues, to false official information, criminal enterprises, and impure street drugs. The new book is co-edited by Rick Doblin, a Kennedy School graduate who started MAPS in 1986, and by a colleague named Brad Burge. They drew material from the MAPS Bulletin, a magazine that is sent to members and has included a dazzling array of articles, some gathered by guest editors such as David Jay Brown. During the decade ...
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Huffington Post article
Update: Electrical problem blamed for Genesee house fire
West Seattle Blog - about 5 years
(Photo by Christopher Boffoli for WSB) 6:27 PM: Thanks to everybody who sent tips about the fire callout in the Genesee area. It’s a single-family-house fire call in the 4000 block of 52nd SW (map). More shortly. 6:36 PM UPDATE: From the fire scene, Christopher Boffoli reports for WSB: SFD confirms fire tapped. No injuries. House was unoccupied at the time. No word on the cause. Fire investigators coming out. (Christopher says there was lots of smoke when he got to the scene minutes after the initial call, though.) 7:03 PM UPDATE: Investigators are on the scene and suspect the fire started in or near the washer/dryer area. (Photo by WSB co-publisher Patrick Sand) Most of the remaining units are being dismissed from the scene now, as operations wrap up. It was a full-size callout originally, though, as this photo shared by Gary Mullin shows: 8:28 PM UPDATE: SFD confirms an electrical malfunction in the laundry room is to blame – details here.
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West Seattle Blog article
Free Radicals: The Secret Anarchy of Science, By Michael BrooksLitmus: Short ... - The Independent
Google News - over 5 years
The subjects of the stories include Einstein, Pavlov, Joseph Swan (of electric light fame), and many lesser-known names (some – Kary Mullis, Arno Penzias, and Robert Wilson – also appear in Free Radicals) who made major discoveries
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Google News article
Plant spirit medicine - Common Ground.ca
Google News - over 5 years
The Nobel Prize-wining biochemist Kary Mullis has claimed he came up with the idea for the “polymerase chain reaction,” a scientifically revolutionary technique for copying fragments of DNA, while under the influence of LSD
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Google News article
The REAL rats in the lab? Scientists!: FREE RADICALS: THE SECRET ANARCHY OF ... - Daily Mail
Google News - over 5 years
The chemist who first worked out how to read the alphabet of DNA, a lowly Californian scientist called Kary Mullis, did it with the help of taking LSD. He admitted this openly - though not perhaps to the committee which awarded him a Nobel Prize
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Google News article
Il Nobel Montagnier: "Il dna si teletrasporta da cellula a cellula" - eInformazione.it
Google News - over 5 years
Nel 1983 Kary Mullis ha inventato la PCR, un sistema per riprodurre velocemente copie identiche di un Continua a leggere dalla fonte originale: RLI- In caso di problemi riguardanti questo articolo possiamo essere contattati tramite il nostro modulo di
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Google News article
York Township girl's chicken study wins Google Science Fair - Yorkdispatch.com
Google News - over 5 years
Dean Kamen, inventor of the Segway; Vinton Cerf, the vice president of Google; and Kary Mullis, a Nobel Prize-winning chemist, among other science dignitaries. "It was really neat to meet these professionals you read about in magazines," Lauren said
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Google News article
Le révisionnisme du sida: bien vivant sur le net - vih.org
Google News - over 5 years
Le livre est soutenu, et introduit, par un Prix Nobel, Kary Mullis, Prix Nobel de chimie en 1993, père de la technique PCR, qui va, par ses provocations, augmenter le niveau de confusion. Kary Mullis, tout Nobel qu'il soit, se montre incompétent en ce
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Google News article
Nobel laureates to speak at MSU - The Bozeman Daily Chronicle
Google News - over 5 years
Nobel Laureates Dick Taylor, Sir Richard Roberts, Carolyn "Carol" Greider and Kary Mullis will also attend. The Museum of the Rockies has distributed free tickets to Museum members and the general public on a first-come-first-serve basis
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Google News article
Kary Mullis, in un weekend ha cambiato il corso della scienza - Corriere della Sera
Google News - over 5 years
Negli anni 50 la madre di Kary Mullis apostrofava così quel figlio che giocava un pò troppo con il Piccolo chimico. Nel 1984 Kary ha cambiato le prospettive della scienza inventando una tecnica, la PCR (Reazione a Catena della Polimerasi),
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Google News article
Google Science Fair quarter-finalists announced - Gizmag
Google News - over 5 years
Projects will be judged on eight main aspects by a panel that includes Nobel Laureate Dr. Kary Mullis, big name techies from Google and CERN, scientists from National Geographic and Imperial College, and inventors and professors from the Department of
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Google News article
Diagnosticare la depressione dall'analisi del sangue, ora si può - Il Resto del Carlino
Google News - over 5 years
... che in questo modo potranno avere l'appoggio di un dato biologico analitico grazie alle raffinate tecniche analitiche, molecolari e biotecnologiche adoperate nel progetto, che ha tra i consulenti il Premio Nobel per la chimica 1993 Kary Mullis
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Google News article
Una festa per il papà del genoma - La Repubblica
Google News - over 5 years
Non potrebbero passare sotto silenzio i venticinque anni dalla scoperta della Pcr (Polymerase chain reaction) da parte di Kary Mullis, il biochimico statunitense che (dalle 15 di oggi e fino a domani) sarà a Napoli all'hotel Excelsior per partecipare
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Google News article
Redirect AIDS cash to tackling poverty - Edmonton Journal
Google News - over 5 years
Since 1988, when he first realized its absence, Nobel Laureate Kary Mullis has been calling on the HIV/ AIDS industry to produce the scientific research attesting to the causal link between HIV and AIDS -to no avail. Ironically, Mullis's discovery of
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Google News article
Najlepšia značka počítačov: DNA - SME.sk
Google News - over 5 years
Vynašiel ju jeden z najoriginálnejších žijúcich genetikov, nositeľ Nobelovej ceny Kary Mullis. Za zmienku stojí, že časopis New Scientist v čase sporov o Mullisovo prvenstvo pri objave PCR napísal: „Ak zoberieme do úvahy počet právnikov,
Article Link:
Google News article
Global leaders call for a major shift to decriminalize drugs - Yahoo! News Blogs (blog)
Google News - over 5 years
Many successful people have been associated with Cannabis (eg Carl Sagan, Kary Mullis, Richard Branson, Steve Wozniak, Steve Jobs, Tim Lincecum, Francis Crick, and Kareem Abdul-Jabbar). Cannabis can do anything that cotton, trees, and fossil fuels can
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Google News article
Timeline
Learn about memorable moments in the evolution of Kary Mullis
    LATE_ADULTHOOD
  • 2014
    Age 69
    As of 2014, he is a researcher at the Children's Hospital Oakland Research Institute in Oakland, California.
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  • 2011
    Age 66
    Mullis has also invented a UV-sensitive plastic that changes color in response to light, and most recently has been working on an approach for mobilizing the immune system to neutralize invading pathogens and toxins, leading to the formation of his current venture, Altermune LLC, in 2011.
    More Details Hide Details Mullis described this idea this way: It is a method using specific synthetic chemical linkers to divert an immune response from its nominal target to something completely different which you would right now like to be temporarily immune to. Let's say you just got exposed to a new strain of the flu. You're already immune to alpha-1,3-galactosyl-galactose bonds. All humans are. Why not divert a fraction of those antibodies to the influenza strain you just picked up? A chemical linker synthesized with an alpha-1,3-gal-gal bond on one end and a DNA aptamer devised to bind specifically to the strain of influenza you have on the other end will link anti-alpha-Gal antibodies to the influenza virus and presto!--you have fooled your immune system into attacking the new virus.
  • FIFTIES
  • 1998
    Age 53
    Mullis's 1998 autobiography Dancing Naked in the Mind Field, gives his account of the commercial development of PCR, as well as providing insights into his opinions and experiences.
    More Details Hide Details In the book, Mullis chronicles his romantic relationships, use of LSD, synthesis and self-testing of novel psychoactive substances, belief in astrology and an encounter with an extraterrestrial in the form of a fluorescent raccoon. Mullis also received the John Scott Award in 1991, given by the City Trusts of Philadelphia to others including Thomas Edison and the Wright Brothers.
    In his 1998 autobiography, Mullis expressed disagreement with the scientific evidence supporting climate change and ozone depletion, the evidence that HIV causes AIDS, and asserted his belief in astrology.
    More Details Hide Details Mullis claims climate change and the HIV/AIDS connection are due to a conspiracy of environmentalists, government agencies and scientists attempting to preserve their careers and earn money, rather than scientific evidence. Mullis has drawn controversy for his association with prominent AIDS denialist Peter Duesberg, claiming that AIDS is an arbitrary diagnosis only used when HIV antibodies are found in a patient's blood. The medical and scientific consensus is that Duesberg's hypothesis is pseudoscience, HIV having been conclusively proven to be the cause of AIDS and that global warming is occurring because of human activities. Seth Kalichman, AIDS researcher and author of Denying AIDS, "admits that it seems odd to include a Nobel Laureate among the who's who of AIDS pseudoscientists". Mullis also wrote the foreword to the book What If Everything You Thought You Knew About AIDS Was Wrong? by Christine Maggiore, an HIV-positive AIDS denialist who, along with her daughter, died of an AIDS-related illness. A New York Times article listed Mullis as one of several scientists who, after success in their area of research, go on to make unfounded, sometimes bizarre statements in other areas. An article in the Skeptical Inquirer described Mullis as an "AIDS denialist with scientific credentials who has never done any scientific research on HIV or AIDS."
  • 1996
    Age 51
    The anthropologist Paul Rabinow wrote a book on the history of the PCR method in 1996 (entitled Making PCR) in which he discussed whether or not Mullis "invented" PCR or "merely" came up with the concept of it.
    More Details Hide Details Rabinow, a Foucault scholar interested in issues of the production of knowledge, used the topic to argue against the idea that scientific discovery is the product of individual work, writing, "Committees and science journalists like the idea of associating a unique idea with a unique person, the lone genius. PCR is thought by some to be an example of teamwork, but by others as the genius of one who was smart enough to put things together which were present to all, but overlooked. For Mullis, the light bulb went off, but for others it did not. This is consistent with the idea, that the prepared (educated) mind who is careful to observe and not overlook, is what separates the genius scientist from his many also smart scientists. The proof is in the fact that the person who has the light bulb go off never forgets the Ah experience, while the others never had this photochemical reaction go off in their brains."
  • FORTIES
  • 1991
    Age 46
    Mullis and Erlich took Cetus' side in the case, and Khorana refused to testify for DuPont; the jury upheld Mullis's patent in 1991.
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  • THIRTIES
  • 1983
    Age 38
    However, other scientists have written that "the full potential PCR was not realized" until Mullis' work in 1983, and that Mullis' colleagues failed to see the potential of the technique when he presented it to them.
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    Mullis succeeded in demonstrating PCR December 16, 1983.
    More Details Hide Details In his Nobel Prize lecture, he remarked that the success didn't make up for his girlfriend breaking up with him shortly before: "I was sagging as I walked out to my little silver Honda Civic. Neither assistant Fred, empty Beck's bottles, nor the sweet smell of the dawn of the age of PCR could replace Jenny. I was lonesome." He received a $10,000 bonus from Cetus for the invention. Other Cetus scientists, including Randall Saiki and Henry Erlich, were placed on PCR projects to work on evaluating whether PCR could amplify a specific human gene (betaglobin) from genomic DNA. Saiki generated the needed data and Erlich authored the first paper to include utilization of the technique, while Mullis was still working on a paper that would describe PCR itself. A complication at that point was that the DNA polymerase used was destroyed by the high heat used at the start of each replication cycle and had to be replaced. In 1986, Saiki started to use Thermophilus aquaticus (Taq) DNA polymerase to amplify segments of DNA. The Taq polymerase was heat resistant and would only need to be added once, thus making the technique dramatically more affordable and subject to automation. This has created revolutions in biochemistry, molecular biology, genetics, medicine and forensics.
    In 1983, Mullis was working for Cetus Corp. as a chemist.
    More Details Hide Details That spring, according to Mullis, he was driving his vehicle late one night with his girlfriend, who was also a chemist at Cetus, when he had the idea to use a pair of primers to bracket the desired DNA sequence and to copy it using DNA polymerase; a technique which would allow rapid amplification of a small strand of DNA and become a standard procedure in molecular biology labs. Cetus took Mullis off his usual projects to concentrate on PCR full-time.
    Mullis worked as a DNA chemist at Cetus for seven years; it was there, in 1983, that Mullis invented his prize-winning improvements to the polymerase chain reaction.
    More Details Hide Details After leaving Cetus in 1986, Mullis served as director of molecular biology for Xytronyx, Inc. in San Diego for two years. Mullis has consulted on nucleic acid chemistry for multiple corporations. In 1992, Mullis founded a business with the intent to sell pieces of jewelry containing the amplified DNA of deceased famous people like Elvis Presley and Marilyn Monroe. Mullis is also a member of the USA Science and Engineering Festival's Advisory Board.
  • TWENTIES
  • 1972
    Age 27
    He then received a PhD in biochemistry from the University of California, Berkeley in 1972; his research done in J. B. Neilands' laboratory focused on synthesis and structure of bacterial iron transporter molecules.
    More Details Hide Details Following his graduation, Mullis became a postdoctoral fellow in pediatric cardiology at the University of Kansas Medical School, going on to complete two years of postdoctoral work in pharmaceutical chemistry at the University of California, San Francisco. After receiving his PhD, Mullis left science to write fiction, but quit and became a biochemist at a medical school in Kansas City. He then managed a bakery for two years. Mullis returned to science at the encouragement of friend Thomas White, who later got Mullis a job with the biotechnology company Cetus Corporation of Emeryville, California.
  • 1971
    Age 26
    After DuPont lost out to Roche on that sale, the company unsuccessfully disputed Mullis's patent on the alleged grounds that PCR had been previously described in 1971.
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  • 1966
    Age 21
    Mullis earned a Bachelor of Science (BSc) degree in chemistry from the Georgia Institute of Technology in Atlanta in 1966, during which time he got married and started a business.
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  • CHILDHOOD
  • 1944
    Born
    Mullis was born in Lenoir, North Carolina, near the Blue Ridge Mountains, on December 28, 1944.
    More Details Hide Details His family had a background in farming in this rural area. As a child, Mullis recalls, he was interested in observing organisms in the countryside. He grew up in Columbia, South Carolina, where he attended Dreher High School. He has described his early interest in chemistry, and claims to have learned how to chemically synthesize and build solid state fuel propulsion rockets as a high school student during the 1950s.
Original Authors of this text are noted here.
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