The most populous cities in area code 220 are: Athens, Zanesville, Pataskala, Frazeysburg, and Lancaster.
Other cities in the 220 area code include: Marion, Wellston, Baltimore, Roseville, Chesapeake, Amanda, Galena, Chesterhill, Croton, Patriot, Newark, Delaware, Chillicothe, Steubenville, Marietta, Circleville, Coshocton, Ironton, Cambridge, Martins Ferry, Belpre, Nelsonville, Johnstown, Sunbury, Barnesville, Newcomerstown, Mingo Junction, The Plains, West Portsmouth, Crooksville, West Lafayette, Byesville, Piketon, Somerset, Ashley, Millersport, Tiltonsville, Beverly, Jeffersonville, Pleasantville, Thornville, Prospect, Danville, Williamsport, Newport, Scio, New Holland, Racine, Warsaw, Alexandria, Laurelville, Sugar Grove, Rushville, Belmont, Crown City, Lore City, Vincent, Wilkesville, Adamsville, Lower Salem, Graysville, Guysville, Irwin, Long Bottom, and Mount Perry.
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Athens is a city in and the county seat of Athens County, Ohio, United States. It is located along the Hocking River in the southeastern part of Ohio. A historic college town, Athens is home to Ohio University and is the principal city of the Athens, Ohio Micropolitan Statistical Area. The official population of Athens in the 2010 U.S. Census was 23,832. Athens is a qualified Tree City USA as recognized by the National Arbor Day Foundation.
Zanesville is a city in and the county seat of Muskingum County, Ohio, United States. The population was 25,487 at the 2010 census.
Pataskala is a city in Licking County, Ohio, United States. The population was 14,962 at the 2010 census. Pataskala was a small community until 1996, when what was then the village of Pataskala merged with Lima Township, vastly increasing its population and geographic area.
The 220 area code lies within the Eastern Daylight Time Zone (or EDT). The current time in Eastern Daylight Time is 11:06 PM on Apr 29, 2025.